Effects of environmental shear and buoyancy on simulated supercell interactions

This study examines the role that buoyancy and vertical wind shear play in modulating the relationship between storm interactions and storm severity. Using an idealized numerical model, 240 supercell interactions are simulated under systematically varied amounts of buoyancy and vertical wind shear. Small changes in buoyancy or vertical wind shear have signi cant impacts on post-interaction storm morphology. A wide amount of variation in low-level rotation is seen across the simulation suite. Two-cell storm simulations are not always stronger than one-cell control simulations. Migration of low-level vertical vorticity centers is ubiquitous through all runs, but orientation of and interaction between two storms' gust fronts modulates where the vortic- ity center will end up. Gust fronts in better alignment have more vorticity centers reach an updraft where they are stretched and intensi ed. With re- spect to storm mode, higher buoyancy produced less classic supercells while higher shear produced more classic supercells. High precipitation supercells were favored with two-cell simulations where the second cell was directly to the southwest of the control cell. Secondary cells that were close to the con- trol merged quickly and were often stronger than simulations with large cell separation distance. Further questions remain with trajectories and machine learning algorithms are tthe next steps for a more detailed analysis of this large data set

Cyber Physical Security (CPS) Extension to Air Traffic Management (ATM) Testbed

The Air Traffic Management (ATM) Testbed is being developed at NASA to enable benefit, impact, safety and cost assessments for accelerating the deployment of Concept and Technologies (C&T) in the National Airspace System (NAS). Today, C&T introduction into the NAS takes decades. The primary reason for this is an inability to assess the operational impact of the interaction between the proposed C&T and operationally deployed systems (Realistic Technologies) in terms of NAS-wide safety, traffic flow efficiency, roles and workload of controllers and traffic managers, and impact on airline fleet operations. Transition of C&T to operations requires mathematical modeling and simulation, Human-in-the-Loop (HITL) testing and shadow-mode evaluation driven by operational data. Whereas interaction with the operational system during testing and stages of deployment is not permissible due to safety concerns, it is certainly possible to create a simulation environment that closely mimics the NAS using the same operational systems/hardware for enabling such assessments. This presentation focuses on a proposed Cyber Physical Security extension to the ATM Testbed for creating a modeling and simulation architecture to study how well the Air Traffic Management system will perform and analyze effectiveness of mitigating security measures against particular cyber-attack scenarios

Tachyon Condensation in Superstring Field Theory

It has been conjectured that at the stationary point of the tachyon potential for the D-brane-anti-D-brane pair or for the non-BPS D-brane of superstring theories, the negative energy density cancels the brane tensions. We study this conjecture using a Wess-Zumino-Witten-like open superstring field theory free of contact term divergences and recently shown to give 60% of the vacuum energy by condensation of the tachyon field alone. While the action is non-polynomial, the multiscalar tachyon potential to any fixed level involves only a finite number of interactions. We compute this potential to level three, obtaining 85% of the expected vacuum energy, a result consistent with convergence that can also be viewed as a successful test of the string field theory. The resulting effective tachyon potential is bounded below and has two degenerate global minima. We calculate the energy density of the kink solution interpolating between these minima finding good agreement with the tension of the D-brane of one lower dimension.Comment: 41 pages, LaTeX, 1 figure. Added two reference

Constrained BV Description of String Field Theory

In the conventional BV description of string field theory, the string field Phi is split as Phi = Psi+Psi* where Psi includes all states with ghost number less than or equal to G and describes the spacetime fields, and Psi* includes all states with ghost number >G and describes the spacetime antifields. A new approach is proposed here in which separate string fields Psi and Psi* of unrestricted ghost number describe the spacetime fields and antifields. The string antifield Psi* is constrained to satisfy Psi* = {\partial L}/{\partial(Q Psi)} where L is the BV Lagrangian and Q is the worldsheet BRST operator. Dirac antibrackets are defined using this constraint, and the resulting description is equivalent to the conventional BV description for open and closed bosonic string field theory. For open superstring field theory, this constrained BV description is much simpler than the conventional BV description and allows the BV action to be expressed in the same WZW-like form as the classical action.Comment: 21 pages harvmac te

Nanoelectronic Solutions for Hardware Security

Information security has emerged as an important system and application metric. Classical security solutions use algorithmic mechanisms that address a small subset of emerging security requirements, often at high energy and performance overhead. Further, emerging side channel and physical attacks can compromise classical security solutions. Hardware-based security solutions overcome many of the limitations of classical security while consuming less energy and improving performance. Nanoelectronics-based hardware security preserves all of these advantages while enabling conceptually new security mechanisms and security applications. This paper highlights nanoelectronics based security capabilities and challenges. The paper describes nanoelectronics-based hardware security primitives for device identification, digital forensics, and tamper detection. These primitives can be developed using the unique characteristics of emerging nanoelectronic devices such as complex device and system models, bidirectional operation, and temporal drift of state variables. We also identify important desiderata and outstanding challenges in nanoelectronics-based security

Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia

Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus (T2DM). It has also been implicated in the progression of long-term diabetes complications, including microvascular and macrovascular dysfunction. Excess nourishment and a sedentary lifestyle leads to glucose and fatty acid overload, resulting in production of ROS. Additionally, reaction of glucose with plasma proteins forms advanced glycation end products, triggering production of ROS. These ROS initiate a chain reaction leading to reduced nitric oxide availability, increased markers of inflammation and chemical modification of lipoproteins, all of which may increase the risk of atherogenesis. With the postulation that hyperglycaemia and fluctuations in blood glucose lead to generation of ROS, it follows that aggressive treatment of fasting and postprandial hyperglycaemia is important for prevention of micro and macrovascular complications in T2DM

Environmental gradients and the evolution of successional habitat specialization: A test case with 14 Neotropical forest sites

https://www.scopus.com/inward/record.url?eid=2-s2.0-84939570316&partnerID=40&md5=fcadae8e6c274e8b7efca96099304a7cSuccessional gradients are ubiquitous in nature, yet few studies have systematically examined the evolutionary origins of taxa that specialize at different successional stages. Here we quantify successional habitat specialization in Neotropical forest trees and evaluate its evolutionary lability along a precipitation gradient. Theoretically, successional habitat specialization should be more evolutionarily conserved in wet forests than in dry forests due to more extreme microenvironmental differentiation between early and late-successional stages in wet forest. We applied a robust multinomial classification model to samples of primary and secondary forest trees from 14 Neotropical lowland forest sites spanning a precipitation gradient from 788 to 4000 mm annual rainfall, identifying species that are old-growth specialists and secondary forest specialists in each site. We constructed phylogenies for the classified taxa at each site and for the entire set of classified taxa and tested whether successional habitat specialization is phylogenetically conserved. We further investigated differences in the functional traits of species specializing in secondary vs. old-growth forest along the precipitation gradient, expecting different trait associations with secondary forest specialists in wet vs. dry forests since water availability is more limiting in dry forests and light availability more limiting in wet forests. Successional habitat specialization is non-randomly distributed in the angiosperm phylogeny, with a tendency towards phylogenetic conservatism overall and a trend towards stronger conservatism in wet forests than in dry forests. However, the specialists come from all the major branches of the angiosperm phylogeny, and very few functional traits showed any consistent relationships with successional habitat specialization in either wet or dry forests. Synthesis. The niche conservatism evident in the habitat specialization of Neotropical trees suggests a role for radiation into different successional habitats in the evolution of species-rich genera, though the diversity of functional traits that lead to success in different successional habitats complicates analyses at the community scale. Examining the distribution of particular lineages with respect to successional gradients may provide more insight into the role of successional habitat specialization in the evolution of species-rich taxa

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Summary Background Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. Methods To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. Findings We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07–1·15, p=1·84 × 10−9) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86–0·93, p=6·46 × 10−9). Cannabis use disorder and cannabis use were genetically correlated (rg 0·50, p=1·50 × 10−21), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. Interpretation These findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder. Funding National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing; The European Commission, Horizon 2020; National Institute of Child Health and Human Development; Health Research Council of New Zealand; National Institute on Aging; Wellcome Trust Case Control Consortium; UK Research and Innovation Medical Research Council (UKRI MRC); The Brain & Behavior Research Foundation; National Institute on Deafness and Other Communication Disorders; Substance Abuse and Mental Health Services Administration (SAMHSA); National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council (NHMRC) Australia; Tobacco-Related Disease Research Program of the University of California; Families for Borderline Personality Disorder Research (Beth and Rob Elliott) 2018 NARSAD Young Investigator Grant; The National Child Health Research Foundation (Cure Kids); The Canterbury Medical Research Foundation; The New Zealand Lottery Grants Board; The University of Otago; The Carney Centre for Pharmacogenomics; The James Hume Bequest Fund; National Institutes of Health: Genes, Environment and Health Initiative; National Institutes of Health; National Cancer Institute; The William T Grant Foundation; Australian Research Council; The Virginia Tobacco Settlement Foundation; The VISN 1 and VISN 4 Mental Illness Research, Education, and Clinical Centers of the US Department of Veterans Affairs; The 5th Framework Programme (FP-5) GenomEUtwin Project; The Lundbeck Foundation; NIH-funded Shared Instrumentation Grant S10RR025141; Clinical Translational Sciences Award grants; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences.Peer reviewe

ENIGMA-anxiety working group : Rationale for and organization of large-scale neuroimaging studies of anxiety disorders

Altres ajuts: Anxiety Disorders Research Network European College of Neuropsychopharmacology; Claude Leon Postdoctoral Fellowship; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, 44541416-TRR58); EU7th Frame Work Marie Curie Actions International Staff Exchange Scheme grant 'European and South African Research Network in Anxiety Disorders' (EUSARNAD); Geestkracht programme of the Netherlands Organization for Health Research and Development (ZonMw, 10-000-1002); Intramural Research Training Award (IRTA) program within the National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, MH002781); National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, ZIA-MH-002782); SA Medical Research Council; U.S. National Institutes of Health grants (P01 AG026572, P01 AG055367, P41 EB015922, R01 AG060610, R56 AG058854, RF1 AG051710, U54 EB020403).Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders

In-situ estimation of ice crystal properties at the South Pole using LED calibration data from the IceCube Neutrino Observatory

The IceCube Neutrino Observatory instruments about 1 km3 of deep, glacial ice at the geographic South Pole using 5160 photomultipliers to detect Cherenkov light emitted by charged relativistic particles. A unexpected light propagation effect observed by the experiment is an anisotropic attenuation, which is aligned with the local flow direction of the ice. Birefringent light propagation has been examined as a possible explanation for this effect. The predictions of a first-principles birefringence model developed for this purpose, in particular curved light trajectories resulting from asymmetric diffusion, provide a qualitatively good match to the main features of the data. This in turn allows us to deduce ice crystal properties. Since the wavelength of the detected light is short compared to the crystal size, these crystal properties do not only include the crystal orientation fabric, but also the average crystal size and shape, as a function of depth. By adding small empirical corrections to this first-principles model, a quantitatively accurate description of the optical properties of the IceCube glacial ice is obtained. In this paper, we present the experimental signature of ice optical anisotropy observed in IceCube LED calibration data, the theory and parametrization of the birefringence effect, the fitting procedures of these parameterizations to experimental data as well as the inferred crystal properties.</p